Transplant ineligible multiple myeloma

Authored by Manni Mohyuddin, published on 2026-02-13 16:25:25.0

Treatment algorithm for transplant ineligible multiple myeloma. For frail patients, anti-CD38 best tolerated drug, other agents can be added as tolerable.

  1. Backbone regimen: CD38 mAb + Len/dex
    Dexamethasone should be discontinued by month 6, and taper started Cycle 3 onwards
    • Discuss the addition of once a week bortezomib*
      <p>* If willing to accept increased risk of neuropathy for better PFS/MRD (we do not know if OS better).</p><p><br></p><p><a href="https://drive.google.com/file/d/1XdFGsqgS-oh8ytKPUZ6IYXOq_CvybT7_/view?usp=sharing">What bortezomib adds trade off image</a></p>
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