Toxicity management for duodenal/gastric ulceration after pancreas SBRT

Authored by Nina Sanford, published on 2026-02-22 16:24:35.0

How Dr. Nina Sanford, Associate Professor and Chief of Gastrointestinal Radiation at UT Southwestern manages duodenal/gastric ulceration after pancreas Stereotactic Body Radiation Therapy (SBRT). Originally posted on YouTube "Managing Toxicity from Radiotherapy to Upper GI Cancers (esophagus, pancreas, liver)" by Dr. Sanford.

Duodenal/Gastric Ulceration after Pancreas SBRT
- Months–years after SBRT
  - Epigastric pain / melena / anemia / nausea
    - Suspect ulceration
      - EGD
        
        • Diagnose • Treat bleeding if present
        
        Bleeding only
      - Medical therapy
        
        • PPI (daily or BID) • Sucralfate
        
        Consider stent

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