Thoracic solid tumour resectability in the ERA of Immunotherapy

Authored by Andrea Billè, published on 2026-04-14 03:49:37.0

Resectability Matrix in the ERA of ImmunotherapyThere is no consensus reached for some stage features. Resectability decision making is key for patient to be eligible for chemo Immunotherapy. There are guidelines but there is no algorithm to help tumour board or surgeons to define resectability in N2 category or locally advanced cancer (T3 / T4).

  1. N1 and N2 lymph node station involved, specifying location
    The porpoise is to introduce the stations involved, the number and also if they are bulky or not
    • Offer resectability options, in terms of operation
      base on tumor location patient may have: a lobectomy, a bilobectomy a pneumonectomy or an ertrial or bronchial slleve
      • Neo adjuvant Chemo and Immunotherapy
        • Surgery
          • Perioperative Immunotherapy
      • Chemo RT
        • Immunotherapy
          • Salvage surgery
            Consider re staging before offer surgery
  2. Insert maximum tumor size and or extension and structured invaded in case of a T4 tumour
    • Offer resectability options, in terms of operation
      base on tumor location patient may have: a lobectomy, a bilobectomy a pneumonectomy or an ertrial or bronchial slleve
      • Neo adjuvant Chemo and Immunotherapy
        • Surgery
          • Perioperative Immunotherapy
      • Chemo RT
        • Immunotherapy
          • Salvage surgery
            Consider re staging before offer surgery
  3. T2b (4 cm and above) and N0
    • Upfront surgery
      • Immunotherapy
        Adjuvant treatment
    • Neo adjuvant Chemo and Immunotherapy
      • Surgery
        • Perioperative Immunotherapy
tosprivacyEORTC resectability consensusNivolumab as IOPembrolizumabPAcific trial with durvalumabPacific trial durvalumab post chemo RTPembrolizumabNivolumabperioperative durvalumabPembrolizumab as adjuvant treatmentatezolizumab