Refractory multiple myeloma

Authored by Vincent Rajkumar, published on 2026-06-04 18:20:14.0

Refractory multiple myeloma treatment algorithm. There are many options. But we need more. Good news is more are coming.Active drugs in multiple myeloma reference. mSMART 4.0 risk stratification of active multiple myeloma.

  1. Refractory to Imid, PI, anti CD38, and BCMA approaches
    • Treatment options
      Venetoclax if t(11;14) Talquetamab or Talquetamab combination Other non-BCMA immunotherapy (eg., cevostamab or GPRC5D CART on a clinical trial) Alkylator-based regimens (VCd, KCd, IV melphalan) BCMA Bispecific Combinations Selinexor-based regimen Combination chemo (VDT-PACE, CVAD, DPACE) Bendamustine-based regimens
tosprivacyLong-Term Follow-Up Results of Lenalidomide, Bortezomib, and Dexamethasone Induction Therapy and Risk-Adapted Maintenance Approach in Newly Diagnosed Multiple MyelomaTalquetamab plus Teclistamab in Relapsed or Refractory Multiple Myeloma