Authored by Vincent Rajkumar, published on 2026-04-17 07:44:14.0
Treatment algorithm for newly diagnosed myeloma patients. Dr. Rajkumar is a contributing editor to the International Myeloma Foundation (https://www.myeloma.org/frontline-treatment-options).
Standard Risk
Dara-VRd or Isa-VRd
Early ASCT after 4 cycles if eligible and interested
Len or Len plus Anti-CD38 (Dara/lsa) maintenance
Len or Lenalidomide plus Anti-CD38 (Dara/Isa) maintenance
High Risk
Dara-VRd or Isa-VRd
Early ASCT if eligible
Doublet maintenance with Len plus PI or Anti-CD38 (Dara/lsa)