Newly Diagnosed Myeloma

Authored by Vincent Rajkumar, published on 2026-02-12 23:31:47.0

Treatment algorithm for newly diagnosed myeloma patients.  Dr. Rajkumar is a contributing editor to the International Myeloma Foundation (https://www.myeloma.org/frontline-treatment-options).

  1. Standard Risk
    • Dara-VRd or Isa-VRd
      • Early ASCT after 4 cycles if eligible and interested
        • Len or Len plus Anti-CD38 (Dara/lsa) maintenance
      • Len or Lenalidomide plus Anti-CD38 (Dara/Isa) maintenance
  2. High Risk
    • Dara-VRd or Isa-VRd
      • Early ASCT if eligible
        • Doublet maintenance with Len plus PI or Anti-CD38 (Dara/lsa)
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