Authored by Vincent Rajkumar, published on 2026-03-24 03:17:58.0
Monoclonal Gammopathy of Undetermined Significance (MGUS) is diagnosed via blood and urine tests that detect abnormal M-proteins, typically identified during routine checkups. It is defined by a serum M-protein level < 3 g/dL, < 10% plasma cells in the bone marrow, and an absence of end-organ damage (no bone lesions, anemia, or kidney failure).
Potential New MGUS
No clinical concerns, and
• Low Risk*, or
• IgM M protein <1.5 gm/dl, or
• Light Chain abnormality only
with FLC ratio between 0.125-8.0
Provisional Diagnosis of MGUS
Bone marrow biopsy and bone imaging
can be deferred